Trazodone's Unlikely Rise—and Complicated Future—in American Psychiatric Practice
Once dismissed as a second-tier antidepressant, trazodone quietly became one of the most prescribed psychiatric medications in the United States—largely for uses its original approval never anticipated. An examination of its pharmacology, real-world prescribing data, and evolving clinical guidelines reveals both why that ascent happened and why the conversation around trazodone is growing more complicated.
